The process of EDC-NHS cross-linking of reconstituted collagen fibres increases collagen fibrillar order and alignment
We describe the production of collagen fibre bundles through a multi-strand, semi-continuous extrusion process.Cross-linking using an EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide), NHS BEETS (N-hydroxysuccinimide) combination was considered.Atomic Force Microscopy and Raman spectroscopy focused on how cross-linking affected the collagen fibri